Azithromycin is an azalide antibiotic, a subclass of macrolide antibiotic. It acts by binding to the 50s ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis.
Azithromycin has been shown to be active against most strains in the following microorganisms, both In vitro and in clinical infections:
Gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes.
Gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Escherichia coli.
Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumoniae, Bacteroides fragilis, Legionella pneumophila, oxoplasma gondii.
Azithromycin is indicated for infections caused by susceptible organisms in-
1. Upper respiratory tract infections including sinusitis, pharyngitis and tonsillitis
2. Lower respiratory tract infections including bronchitis, acute bacterial exacerbations of chronic obstructive pulmonary disease (COPD)
3. Otitis media
4. Skin and soft tissue infections including cellulitis, pyoderma, erysipelas, wound infections
5. Diarrhea, Shigellosis
6. Sexually transmitted diseases, especially in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis
7. Genital ulcer disease in men due to Haemophilus ducreyi (chancroid)
8. Mild or moderate typhoid due to multiple-antibacterial resistant organismsProphylaxis against a-hemolytic (viridans group) streptococcal bacterial endocarditis.
Other infections including odontogenic infections, bartonella infections, toxoplasmosis, babesio